Vol 22, No 2 (2025)

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Full Issue

Articles

Features of treatment of purulent-nflammatory wound complications after relapa-rotomies "on demand" in emergency abdominal surgery

Klimovich I.N., Maskin S.S., Shmyrev K.А., Golbraykh V.А., Derbentseva T.V., Aleksandrov V.V., Orlov D.V., Dubrovin I.A.

Abstract

In patients with emergency abdominal surgical pathology (EASP), purulent-inflammatory wound complications (PIWC) after emergency relaparotomy (ERLT) “on demand” develop in 30–65 % of cases. ERLT is performed in the first phase of wound healing (3-7 days), during this period of time, inflammatory processes are clearly expressed in the wound: the wound is oversaturated with inflammatory mediators (prostaglandins, inflammatory cytokines, chemokines) leading to vascular contraction and increased permeability of the vascular wall, local acidosis, increased catabolism, migration of leukocytes into the wound, and wound ischemia is increased due to the compressive effect of the sutures. These components of the first phase of wound healing, during relaparotomy by removing sutures, significantly increase the risk of infection and complicate the treatment tasks. The aim of this study is to improve the treatment outcomes of patients with EASP after ERLT by using improved methods of treating PIWC. Materials and methods: Clinical studies were conducted on 129 patients with various types of EASP who underwent ERLT, of which 87 were retrospective (comparison group) and 42 were prospective (main group). The results showed that in the main group, the use of improved methods of treating PIWC based on closed prolonged irrigation of wounds with antibiotics and antiseptics, with anaerobic flora, additional insufflation of the wound with oxygen, allow earlier elimination of anaerobic non-clostridial flora (ANF), replacement of mixtures of facultative anaerobic bacteria with a monoculture, and avoidance of nosocomial infection. Compared to the comparison group, the updated algorithm for treating suppurating wounds reduced the time of the possibility of applying secondary sutures by (6 ± 1) days, reduced the duration of hospitalization by (10 ± 2) days, and mortality by (4.5 ± 0.5) %. Conclusions. The proposed improved methods of closed treatment of PIWC after ERLT allow to avoid complications from the wound (phlegmon, eventration), statistically significantly reduce the duration of hospitalization and mortality.

Volgograd Journal of Medical Research. 2025;22(2):6-12
pages 6-12 views

Studying the indicator of the degree of activity of regulatory systems in university students (based on the example of the indicator of the degree of centralization of management of central levels of regulation)

Puzyrev V.G.

Abstract

This paper examines the degree of centralization of management in the context of regulatory activity, which plays an important role in human life. The aim of the work is to identify patterns and changes in the distribution of activity indicators of regulatory systems, in particular, the degree of centralization of management between the studied groups. The method of variational heart rate monitoring, developed by the Institute of Biomedical Problems of the Russian Academy of Medical Sciences, was used to assess the activity of regulatory systems. The study involved two groups: a control group and a group of humanities students, who were assigned based on gender and course of study. The total number of respondents was 235 students. The age indicators, taking into account the course of study, were: for 1st year – (18.3 ± 2.1) years; for the 3rd course – (20.5  ± 1.9) years; for the 6th year – (23.8 ± 2.2) years, respectively, 1, 2, 3 age gradations. Data analysis showed that the most common indicators were a gradual and sharp decrease in regulatory activity, typical for 37.98 and 37.43 %, respectively. At the same time, a sharp decrease in regulatory activity is most pronounced in the group of 1st-year students. The distribution of participants by gender showed that men are most characterized by a moderate decrease in regulatory activity, while women experience a sharp decrease in this indicator, which occurs in 36.95 and 43.68 %, respectively. A comparison of the two groups of study participants showed that normal regulatory activity was 3.16 % more common in the control group than in the student group. The conducted research has shown that it is necessary to study and review approaches to managing and supporting students in the learning process.

Volgograd Journal of Medical Research. 2025;22(2):13-18
pages 13-18 views

Endovascular correction in a patient with diabetic foot syndrome with TASC D leg artery lesion (clinical case)

Parovatkin M.I., Matyukhin V.V., Legkii A.V., Golbraykh V.А., Strepetov N.N., Maskin S.S.

Abstract

According to the Russian Ministry of Health, diabetes mellitus currently accounts for 3.3 % of the Russian population. The most dangerous consequences of the global diabetes epidemic are systemic vascular complications, in particular, lesions of the peripheral vessels of the lower extremities. A necessary condition for stopping infectious and trophic processes in case of obstruction of limb vessels is the restoration of the main blood flow. In recent years, preference has been given to endovascular revascularization methods. The aim of the work is to demonstrate a clinical observation and evaluate the effectiveness of endovascular transluminal balloon angioplasty (TLBA) for the correction of TASC D leg lesions in a patient with diabetic foot syndrome (DFS), as well as to analyze the literature data on the use of this technique in lower extremity vascular lesions. Material and methods. The clinical part of the work was carried out on the basis of the surgical departments of the State Healthcare Institution City Clinical Hospital of Emergency Medical Care No. 25 of Volgograd. Traditional research methods were used to diagnose lower extremity vascular lesions: duplex scanning of the lower extremity vessels, selective angiography of the arteries of the left lower extremity. The information bases were the following data: PubMed, CyberLeninka, Google Scholar, Medline, eLIBRARY and the Russian Diabetes Registry of 2021. Results. A review of studies devoted to the study of the possibilities of lower extremity revascularization in the treatment of patients with diabetic foot syndrome shows that TLBA in patients with critical limb ischemia to preserve it costs the state 4–7 times less than amputations and subsequent stages of prosthetics and rehabilitation. Reconstructive surgeries give positive results of limb revascularization in 70–80 %. The article presents a clinical observation demonstrating the possibility and effectiveness of endovascular balloon angioplasty as one of the options for endovascular correction in purulent-necrotic lesions of the foot in a patient with diabetic foot syndrome against the background of TASC D leg artery lesions. Conclusion. Transluminal balloon angioplasty against the background of critical ischemia of the leg arteries in patients with diabetes mellitus can be considered as the operation of choice for limb salvation.

Volgograd Journal of Medical Research. 2025;22(2):19-25
pages 19-25 views

Dynamics of changes in the size of the mandibular branch during the period of re-movable occlusion

Shkarin V.V., Makedonova Y.A., Didenko I.V., Dmitrienko T.D., Kerobyan V.I.

Abstract

The relevance of the study is determined by the fact that there is still not enough information about age-related changes in the mandibular branch associated with teething and growth of the alveolar part of the mandible. Purpose. To determine the dynamics of changes in the size of the mandibular branch and its parts during the period of removable occlusion. Material and methods. The gnathic part of the facial part of the head was measured on 53 sets of teleradiographs and orthopantomograms. The study was retrospective and randomized. Groups of children were formed taking into account the change of teeth. The continuation of the occlusal line served as the border between the upper and lower part of the jaw branch. Results and discussion. During the analysis, it was found that during the period of occlusion of milk teeth, the height of the branch was (42.21 ± 2.48) mm. At the same time, the ratio of the height of the upper occlusive-articular part of the branch to the lower occlusive-alveolar part averaged 1.15 ± 0.13 and visually they looked of equal size. With the eruption of permanent teeth and the change of milk teeth, the vertical size of the branch increased, and the ratio of their parts changed. After the eruption of the second permanent molars, the height of the branch was (62.87 ± 3.62) mm, which was significantly higher than in children of other groups (p ˂ 0.05). At the same time, the height of the upper occlusal articular part was (40.23 ± 2.01) mm, and the lower part was (22.64 ± 1.78) mm. The ratio of the height of the upper part of the branch to the lower part was on average 1.78 ± 0.18. Conclusion. The results of the study can be used in clinical practice for the differential diagnosis of anomalies and variations of the mandibular branch, affecting the typological features of the growth of the gnathic part of the face.

Volgograd Journal of Medical Research. 2025;22(2):26-33
pages 26-33 views

Variants of proportionality of gonional-occlusal and condylar-occlusal height of the mandibular branch in physiological occlusion of permanent teeth

Dmitrienko T.D., Yagupova V.T., Kerobyan V.I.

Abstract

The variability in the size of the branches of the lower jaw determines the relevance of assessing the proportionality of its main parts. In intravital conditions, X-ray methods of examination occupy a special place in diagnosis. Purpose. To determine the main vertical parameters of the mandibular branch and its components in physiological occlusion of permanent teeth. Material and methods. An analysis of 74 sets of radiographs, including orthopantomograms and teleradiographs of people with signs of physiological occlusion, was carried out. The mandibular branch was conditionally divided by a line running through the distal occlusal point into two sections, the upper occlusal articular and the lower occlusal gonional. Results and discussion. In the course of the analysis of radiographs of people with physiological types of occlusion, it was found that the height of the mandibular branch averaged (61.28 ± 1.24) mm. The ratio of the upper part to the lower part was 1.97 ± 0.07. The relative ratio in the range from 1.8 to 2.1 allowed us to distinguish 3 groups. The first group included radiographs in which the relative indicator corresponded to the mean values (1.8–2.1). The second group included radiographs with a reduced ratio of parts of the mandibular branch (less than 1.7). In the third group, the ratio of parts of the mandibular branch exceeded 2.2. Conclusion. On average, the height of the upper occlusal articular part of the branch was twice the size of the lower occlusal gonional part, which can be used both in the clinic of orthodontics and maxillofacial surgery when planning operations to model the branch of the lower jaw.

Volgograd Journal of Medical Research. 2025;22(2):34-40
pages 34-40 views

Variants of the position of the first permanent molars relative to the pterygoid vertical plane on a lateral teleradiography

Shkarin V.V., Didenko I.V., Dmitrienko T.D., Yagupova V.T., Kerobyan V.I.

Abstract

Determination of the position of key teeth in the gnathic part of the facial region of the head according to teleradiography data is an urgent task of clinical orthodontics. Purpose. To determine the variants of the position of the first permanent molars relative to the pterygoid vertical plane on the lateral teleradiograph and to develop a model for predicting the optimal position of key teeth in the structure of the gnatic part of the face. Material and methods. The analysis of 48 teleradiographs of young people with occlusion physiology and 23 teleradiographs of children in different periods of removable occlusion was carried out. The analysis used the Ralph E. McDonald method and the developed original mole for predicting the optimal position of the occlusion keys. Results and discussion. The analysis of teleradiographs revealed that the distance from the pterygoid vertical plane PTV to the distal surface of the upper first permanent molar in the group as a whole was (18.37 ± 3.62) mm. The average distance between the articular and spinal verticals in the analyzed group was (89.12 ± 2.8) mm. At the same time, the sagittal size averaged (58.74 ± 1.57) mm, and the anterior size was (30.41 ± 1.02) mm. A relatively stable indicator was the ratio of the sagittal size of the gnathic complex to the posterior part, which averaged 1.5 ± 0.06. Conclusion. In the course of the analysis, an optimal model for predicting the first permanent molars was developed, which is an objective method of analysis in different periods of ontogenesis, regardless of the sagittal size of the gnatic calving of the face. The ratio of the condyllospinal size to the coefficient of 1.5 determines the position of the medial surface of the first molar, which can be used in the orthodontics clinic to diagnose anomalies in the position of teeth and dental arches.

Volgograd Journal of Medical Research. 2025;22(2):41-49
pages 41-49 views

Location of the upper first premolars relative to the Bimler stess-axis in variants of physiological occlusion and features of the chin protrusion

Yagupova V.T., Dmitrienko T.D., Kerobyan V.I.

Abstract

The issues of determining the methods of orthodontic treatment with and without tooth extraction remain relevant to this day. A special place is occupied by methods with the removal of the first premolars, and the orientation to the position of the Bimler stess-axis is perhaps the only criterion for determining the method of extraction therapy. However, we have not found any information about the position of the Bimler line, taking into account the individuality of the dentition-jaw system. Purpose. To determine the location of the upper first premolars relative to the Bimler stess-axis in different trusal variants of the dentoalveolar arches and latitudinal parameters of the chin protrusion. Material and methods. The study was retrospective, with distribution into groups that took into account variants of physiological protrusion and incisor retrusion, as well as latitudinal variants of the chin protrusion, along the posterior protrusion of which the Bimler strass axis passed. Using the computer program PowerPoint, a circle was inscribed on the photo of the teleradiograph, which passed through the anterior and posterior occlusal points and the upper point of the articular head. From the center of the circle to the posterior convexity of the contour of the chin symphysis, the Bimler strass axis was drawn. The position of the first upper premolars relative to the landmark was visually assessed. Results and discussion. It was noted that with the protrusive position of the incisors, in people with physiological occlusion, there was a displacement of the first premolars anterior to the Bimler stress axis. At the same time, the location of the first upper premolars behind or on the Bimler line, in people with retrusin-type arches, is not a contraindication to extraction treatments. The width of the chin protrusion influenced the position of the Bimler stress axis. Conclusion. In the course of the study, it was found that in the mesotrusal type of dental arches, in people with wide chin variants, the location of the Bimler stress axis behind the upper premolars is not a sign of their mesial displacement relative to the structures of the skull. The same is noted for the protrusive type of arches, regardless of the width of the chin protrusion. The data obtained can be decisive in the diagnosis of anomalies and the choice of extraction and non-extraction methods of treatment.

Volgograd Journal of Medical Research. 2025;22(2):50-56
pages 50-56 views

Features of CCND1 and EGFR gene amplification and their correspondence with the expression of CYCLIN D1 and EGFR proteins in the tongue squamous cell carcinoma

Zibirov R.F., Bekhtereva I.A., Mozerov S.А.

Abstract

The purpose of the study: Evaluation tumor cell number with CCND1 and EGFR gene amplification and its correlation with Cyclin D1 and EGFR protein expression in squamous cell carcinoma of the tongue. Material and methods. For cytogenetic examination, smears from 19 cases of squamous tongue cancer were used, after which a biopsy of the corresponding tumor sites was performed. The cytogenetic study was performed by interphase fluorescent in situ hybridization (FISH). The immunohistochemical study was performed using antibodies to Cyclin D1 and EGFR. Results. Amplification of the EGFR and CCND1 genes was detected in the tumor cells of all samples. The number of cells with amplification of the studied genes occupied a wide range. Thus, for the EGFR gene, it ranged from 1 to 59 cells, and for the CCND1 gene, it ranged from 1 to 87 cells. In 100 % of observations, EGFR and CCND1 amplification were combined. Diffuse, mostly moderate EGFR expression was detected in 17 (89 %) of the 19 observations, and focal weak expression was detected in two observations (11 %). Cyclin D1 expression in all analyzed observations was focal, weak and moderate. Conclusion. The cytogenetic features of the tongue squamous cell carcinoma are wide range of cells with amplification of EGFR and CCND1 genes, amounting to 1–59 and 1–87 cells, respectively. Tumors with EGFR amplification correspond to diffuse EGFR protein expression in 89% of cases and focal expression in 11% of cases.
Tumors with CCND1 amplification correspond to the focal expression of Cyclin D1 in all observations.

Volgograd Journal of Medical Research. 2025;22(2):57-62
pages 57-62 views

Evaluation of the effectiveness of the antireflux cuff from the round ligament of the liver in obese patients after longitudinal gastrectomy

Burikov M.А., Shulgin O.V., Kinyakin A.I., Chernyshov Y.K.

Abstract

The purpose. The objective of this study is to evaluate the efficacy and safety of forming an antireflux sleeve from the round ligament of the liver in obese patients after longitudinal gastrectomy (LG) in the prevention of gastroesophageal reflux disease (GERD) compared with standard LG with cruroraphy. Material and methods. A prospective study (2018–2023) included 82 obese patients (BMI ≥35 kg/m²) with confirmed GERD. The primary cohort (n = 42) was administered GERD with the formation of an antireflux cuff from the round ligament of the liver and posterior cruroraphy; the control group (n = 40) received only GERD with cruroraphy. The assessment encompassed a range of methodologies, including clinical (GSRS, SF-36 questionnaires), instrumental (FEGDS, pH-metry, fluoroscopy), and the Clavien-Dindo classification of complications. Statistical analysis was performed using the Mann-Whitney and χ² criteria. Results. Efficiency. After a 12-month period, a complete disappearance of GERD symptoms was observed in 92.9 % of patients in the primary cohort, as compared to 85% in the control group (p = 0.033). The recurrence of gastroesophageal reflux disease (GERD) was observed to occur in 2.4 % (1/42) of the subjects in the study, as compared to 15 % (6/40) of the subjects in the study. Complications. In the main group, 2.4 % of mild complications (bleeding) were registered, while in the control group, 5 % of cases required repeated surgical interventions (e.g., gastric bypass, teres-plasty). Instrumental data. In the primary cohort, Index DeMeester registered at 7.1 (compared to 9.3 in the control group), while the proportion of time spent with a pH below 4 was recorded at 1.7 % (versus 1.38 %). Quality of life. The GSRS questionnaire revealed a statistically significant improvement in the "reflux syndrome" scale among the primary cohort (p = 0.004). The SF-36 demonstrated a significant improvement in the "General health" (77 versus 67 points) and "Social functioning" (100 versus 88) scales. Conclusion. The antireflux cuff, fabricated from the round ligament of the liver, has been demonstrated to reduce the risk of Gastroesophageal Reflux Disease (GERD) recurrence, enhance quality of life, and is deemed safe in patients post-Procedure Related to the Liver (PR). The method has the potential to become a standard in bariatric surgery for patients with obesity and concomitant GERD.

Volgograd Journal of Medical Research. 2025;22(2):63-71
pages 63-71 views

On the need for health-saving educational technologies in university

Popov M.V., Nekhaenko N.E.

Abstract

The article presents a rationale for the need for systematic implementation of health-saving educational technologies as an integral component of modern higher education, since the traditional organization of education provokes risks to the health of students. Objective. To reveal the need to provide health-saving educational technologies in universities. Materials and methods. Analytical formal-pedagogical components were applied. Results and discussion. The article considers the need to implement health-saving educational technologies in higher education institutions. It is determined that the basis of the health-saving process of teaching and upbringing students is a competence-based approach, as a systemic factor in the development of their personal qualities and the formation of a positive attitude towards health. It is emphasized that health-saving technologies are a set of pedagogical methods and organizational measures aimed at minimizing academic overload, preventing stress, optimizing physical activity and forming a health culture not to the detriment of, but for the benefit of educational goals, which can achieve a triune result: maintaining students' health, increasing their motivation and learning efficiency, fulfilling the university's social mission to educate a healthy generation. Conclusion. The introduction of necessary health-saving technologies into the educational process of higher education institutions, promoting a conscious attitude towards health, should be based on the necessary knowledge, skills and abilities of physical, mental, spiritual and social health of students. The implementation of such technologies is a strategic necessity for the university, as it leads to a decrease in the incidence of students, an increase in their adaptive potential, academic success and, ultimately, the quality of training competitive graduates.

Volgograd Journal of Medical Research. 2025;22(2):72-77
pages 72-77 views

Prospects of exoskeletal orthosis of the upper extremities in patients of the older age group

Vorobiev А.А., Andryushchenko F.A., Mazunov A.S., Pisareva E.E., Venskel E.V., Chulkov O.D., Chernov V.O.

Abstract

Introduction. The causes of upper mono- and paraparesis leading to disability are often stroke, myopathy and trauma, the frequency of which increases with age. It is necessary to evaluate the results, features and prospects of using the innovative method of exoskeleton habilitation and rehabilitation in elderly patients. Objective: to demonstrate the possibilities of using the modification of the passive exoskeleton of the upper limbs "EXAR-34" in complex habilitation and rehabilitation of older patients with upper flaccid para- and monoparesis. Materials and methods. The experience of using the EXAR-34 exoskeleton using the anatomical parameterization method in 2 women and 2 men aged 63-86 years with upper flaccid para- and monoparesis of various etiologies is summarized. Goniometry and neurological status examination were used. Results. The design features of the modification of the upper limb exoskeleton of the EXAR series, to be used in elderly patients with upper mono- and paraparesis, are revealed and described. It is demonstrated how, as a result of exoskeleton habilitation and rehabilitation, all patients of the discussed category in a short time managed to steadily increase the volume of abduction and flexion in the shoulder-scapular joints compromised by pathology from the level of significant to insignificant limitation, which significantly improved their quality of life. The concept is outlined and an assessment is given of the positive and negative aspects of the use of passive exoskeletons in a complex of habilitation and rehabilitation measures for mono- and paraparesis in elderly and old people. The expansion of indications is substantiated and the conditions for using a passive exoskeleton in spastic paraplegia are determined. The pathogenetic effects and pathophysiological mechanisms of the influence of the EXAR series exoskeletons on neuromuscular transmission are revealed. Conclusions. The first experience of using the EXAR-34 passive upper limb exoskeleton in older patients with upper flaccid para- and monoparesis indicates good tolerance of the exoskeleton and pronounced habilitation and rehabilitation effects. The expansion of indications for the use of the EXAR-34 exoskeleton is possible due to a group of patients with post-stroke complications in the form of spastic paraplegia, after preliminary botulinum toxin therapy.

Volgograd Journal of Medical Research. 2025;22(2):78-85
pages 78-85 views

Morphological changes in reparative regeneration of soft tissue in rats with compromised type 2 diabetes mellitus during experimental wound process

Kubanova А.B., Smirnov A.V., Timchenko L.D., Kubanov S.I., Dzhikaev G.D., Krayushkin A.I., Samusev R.P., Gurov D.Y., Zamaraev V.S.

Abstract

The aim of the study was to investigate morphological changes and the severity of reparative processes in old rats with experimental wound healing against the background of experimental type 2 diabetes mellitus. Materials and methods. The study was performed on experimental material, sexually mature male Wistar rats aged 18 months, on which type 2 diabetes mellitus (T2DM) was modeled for 6 months. T2DM was induced using streptozotocin (65 mg/kg, 15 min after administration of 230 mg/kg nicotinamide, Sigma-Aldrich, USA). The animals were divided into groups: Group I – a modeled skin wound in rats without diabetes, Group II wound + T2DM, blood glucose level of 12 mmol/l and higher. A wound injury of the skin measuring 20 × 30 mm was excised with a scalpel and histological micropreparations were prepared. Animals were withdrawn from the experiment on days 7, 14, 21 and 28. The morphology of the wound process in rats with T2DM and modeled planar wounds of soft tissues was analyzed. The effect of hyperglycemia on the morphological features of the wound process in old rats was shown. The dynamics of the ratio of neutrophilic leukocytes and macrophages was revealed and the priority role of polymorphonuclear infiltration as a regulator of inflammatory-reparative relationships in the mechanism of wound healing in old rats with experimental T2DM was confirmed.

Volgograd Journal of Medical Research. 2025;22(2):86-93
pages 86-93 views