Spiroheterocyclization of 1-antipyryl-4-aroyl-5-methoxycarbonyl-1 H -pyrrrole-2,3-diones under the action of dimedone

V. A. Lyadov; Лядов В. А.; E. S. Denislamova; Денисламова Е. С.; A. N. Maslivets; Масливец А. Н.

doi:10.31857/S0514749225030146

Spiroheterocyclization of 1-antipyryl-4-aroyl-5-methoxycarbonyl-1H-pyrrrole-2,3-diones under the action of dimedone

Authors: Lyadov V.A.¹, Denislamova E.S.¹, Maslivets A.N.²
Affiliations:
1. Perm National Research Polytechnic University
2. Perm State University
Issue: Vol 61, No 3 (2025)
Pages: 329-332
Section: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
URL: https://bioethicsjournal.ru/0514-7492/article/view/687759
DOI: https://doi.org/10.31857/S0514749225030146
EDN: https://elibrary.ru/EUNDDV
ID: 687759

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Abstract
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Abstract

The interaction of 1-antipyryl-4-aroyl-5-methoxycarbonyl-1H-pyrrole-2,3-diones with dimedone (5,5-dimethylcyclohexanedione-1,3) leads to the formation of 1'-antipyryl-3'-aroyl-4' -hydroxy-6,6-dimethyl-6,7-dihydro-spiro[benzofuran-3,2'-pyrrole]-2,4,5'(1'H, 5H)-triones. Synthesized compounds of interest for pharmacology and medicinal chemistry.

Keywords

1H-pyrrole-2, 3-diones, nucleophilic transformations, spiroheterocyclization, dimedone, enol

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About the authors

V. A. Lyadov

Perm National Research Polytechnic University

Email: katherin85@rambler.ru
ORCID iD: 0000-0002-7267-7577
Russian Federation, prosp. Komsomolskii, 29, Perm, 614990

E. S. Denislamova

Perm National Research Polytechnic University

Author for correspondence.
Email: katherin85@rambler.ru
ORCID iD: 0000-0003-1220-3625
Russian Federation, prosp. Komsomolskii, 29, Perm, 614990

A. N. Maslivets

Perm State University

Email: katherin85@rambler.ru
ORCID iD: 0000-0001-7148-4450
Russian Federation, ul. Bukireva, 15, Perm, 614068

References

Масливец А.Н., Машевская И.В. 2,3-Дигидро-2,3- пирролдионы. Пермь: Пермский госуниверситет, 2005.
Дубовцев А.Ю. Автореф. Дис. … канд. хим. наук. 2017.
Тутынина Н.М., Рачёва Н.Л., Масливец В.А., Алиев З.Г., Масливец А.Н. ЖОрХ. 2013, 49, 101–104. [Tatynina N.M., Racheva N.L., Maslivets V.A., Maslivets A.N., Aliev Z.G. Russ. J. Org. Chem. 2013, 49, 95–98.] doi: 10.1134/S1070428013010168.
Денисламова Е.С., Лядов В.А., Макрушин Д.Е., Рябов В.Г., Дмитриев М.В., Масливец А.Н. ЖОрХ. 2023, 59, 535–540. [Denislamova E.S., Lyadov V.A., Makrushin D.E., Ryabov V.G., Dmitriev M.V., Maslivets A.N. Russ. J. Org. Chem. 2023, 59, 647–651.] doi: 10.31857/S0514749223040122.