Synthesis of ( S )- N -ethyl-2-(5-methylene-4-oxocyclopent-2-en-1-yl)acetamide – a model exomethylidencyclopentenone bioisoster of prostamides

A. M. Gimazetdinov; Гимазетдинов Айрат Маратович; Z. R. Makaev; Макаев Зайнутдин Рамилевич; M. S. Miftakhov; Мифтахов М. С.

doi:10.31857/S0514749225030049

Synthesis of (S)-N-ethyl-2-(5-methylene-4-oxocyclopent-2-en-1-yl)acetamide – a model exomethylidencyclopentenone bioisoster of prostamides

作者: Gimazetdinov A.M.¹, Makaev Z.R.¹, Miftakhov M.S.¹
隶属关系:
1. UFRS RAS
期: 卷 61, 编号 3 (2025)
页面: 246-252
栏目: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
URL: https://bioethicsjournal.ru/0514-7492/article/view/687792
DOI: https://doi.org/10.31857/S0514749225030049
EDN: https://elibrary.ru/ETTOTN
ID: 687792

如何引用文章

全文:

开放存取

##reader.subscriptionAccessGranted##
受限制的访问

订阅或者付费存取

详细
全文:
作者简介
参考
补充文件
统计

详细

The synthesis of the exo-methylidenecyclopentenone amide given in the title of the article from the methyl ester 2-{(1R,2R,5R)-2-[((tert-butyl(dimethyl)silyloxymethyl]-5-(trimethylsilyl)cyclopent-3-en-1-yl}acetic acid.

关键词

allylsilanes, bicyclic δ-lactones, exo-methylidencyclopentenones, cross-conjugated cyclopentenones, prostamides

全文:

作者简介

A. Gimazetdinov

UFRS RAS

编辑信件的主要联系方式.
Email: gimazetdinov@anrb.ru
ORCID iD: 0000-0002-8539-3442

Ufa Institute of Chemistry

俄罗斯联邦, prosp. Oktyabrya, 71, Ufa, 450054

Z. Makaev

UFRS RAS

Email: gimazetdinov@anrb.ru
ORCID iD: 0000-0002-0958-3164

Ufa Institute of Chemistry

俄罗斯联邦, prosp. Oktyabrya, 71, Ufa, 450054

M. Miftakhov

UFRS RAS

Email: gimazetdinov@anrb.ru

Ufa Institute of Chemistry

俄罗斯联邦, prosp. Oktyabrya, 71, Ufa, 450054

参考

Gimazetdinov A.M., Khalfitdinova L.A., Miftakhov M.S. Mendeleev Commun. 2013, 23, 321–322. doi: 10.1016/j.tet.2013.09.047
Vostricov N.S., Spirikhin L.V., Lobov A.N., Gimazetdinov A.M., Zileeva Z.R., Vakhitova Y.V., Macaev Z.R., Pivnitsky K.K., Miftakhov M.S. Mendeleev Commun. 2019, 29, 372–374. doi: 10.1016/j.mencom.2019.07.003
Лоза В.В., Гимазетдинов А.М., Мифтахов М.С. ЖОрХ. 2018, 54, 1575–1620. [Loza V.V., Gimazetdinov A.M., Miftakhov M.S. Russ. J. Org. Chem. 2018, 54, 1585–1629.] doi: 10.1134/S1070428018110015
Bie Q., Dong H., Jin C., Zhang H., Zhang B. Am. J. Transl. Res. 2018, 10, 648–658
Ladin D.A., Soliman E., Escobedo R., Fitzgerald T.L., Yang L.V., Burns C., Dross R.V. Mol. Cancer Ther. 2017, 16, 838–849. doi: 10.1158/1535-7163.MCT-16-0484
Ladin D.A., Nelson M.M., Cota E., Colonna C., Burns C., Robidoux J., Fisher-Wellman K.H., Van Dross-Anderson R. Oncotarget. 2022, 13, 1380–1396. doi: 10.18632/oncotarget.28334
Gimazetdinov A.M., Gataullin S.S., Bushmarinov I.S., Miftakhov M.S. Tetrahedron. 2012, 68, 5754–5758. doi: 10.1016/j.tet.2012.05.036
Гимазетдинов А.М., Альмухаметов А.З., Мифтахов М.С. ЖОрХ. 2019, 55, 938–944. [Gimazetdinov A.M., Al’mukhametov A.Z., Miftakhov M.S. Russ. J. Org. Chem. 2019, 55, 831–836.] doi: 10.1134/S1070428019060137
Аралбаева Г.В., Альмухаметов А.З., Гимазетдинов А.М. ЖОрХ. 2022, 58, 1168–1180. [Aralbaeva G.V., Al’mukhametov A.Z., Gimazetdinov A.M. Russ. J. Org. Chem. 2022, 58, 1589–1599.] doi: 10.1134/S1070428022110057
Gimazetdinov A.M., Al’mukhametov A.Z., Loza V.V., Spirikhin L.V., Miftakhov M.S. Mendeleev Commun. 2018, 28, 546–547. doi: 10.1016/j.mencom.2018.09.033
Gimazetdinov A.M., Al’mukhametov A.Z., Miftakhov M.S. New J. Chem. 2022, 46, 6708–6714. doi: 10.1039/d2nj01003h