IMPROVING THE MEDICAL ABORTION REGIMEN

Objective. To determine the medical and social characteristics of women undergoing termination of pregnancy earlier than 6 weeks and to comparatively evaluate the efficacy and safety of different mifepristone doses for medical abortion (МА). Subjects and methods. A prospective comparative study of the efficacy of different mifepristone doses (600 and 200 mg) for a MA regimen was conducted in 337 and 130 women undergoing termination pregnancy less than 6 weeks’ gestation, respectively. Sonography, vaginal smear bacterioscopy, and in some cases, if indicated, vacuum aspiration, pathomorphological examination of the uterine material were performed. Results. The medico-social portrait of women preferring a reduced mifepristone dose is presented with their late reproductive age (35-43 years), blue-collarjobs, unemployed, mainly legally married women, and parous women who had fewer artificial abortions and a history of MA. Previous genital inflammatory diseases and reproductive losses were determinants in women who are a group at high-risk for post-abortion infectious complications (incomplete abortion and endo-metritis), However, the frequency of complications of MA did not depend on the used dose of mifepristone. The low frequency of complications of MA was ascertained to be associated with a package of preventive measures, such as sanitation of the lower genital tract, ultrasound monitoring of the quality of an abortion.

medical abortion, reduced mifepristone dose, abortion complications